Dr. Zhina Sadeghi is fellowship trained in neurourology, female and reconstructive urologic surgery from University of Michigan. Her expertise of urological diseases includes pelvic organ prolapse, urinary storage and voiding dysfunction (overactive bladder, urinary incontinence, etc.), urethral and bladder neck pathologies (diverticulum, stricture, etc.), neurogenic bladder, radiation cystitis, complications of urinary diversion and stomas, recurrent UTIs, urinary tract fistulas, evaluation and management of hydronephrosis, ureteral obstruction and stricture diseases. She performs outpatient and complex inpatient, vaginal and abdominal, endoscopic, open, and laparoscopic robotic surgeries. Her major scientific interest is translational studies of urinary system storage and voiding dysfunction including pathogenesis of urethral and bladder dysfunction, and investigation of novel multipotent cell therapy, gene therapy and neuromodulation.
Her extensive training over the last 15 years has resulted in 30 publications from translational and clinical research focused on lower urinary tract dysfunction and novel reconstructive treatments. This research studying lower urinary tract dysfunction involved development of different pre-clinical models of urinary incontinence, applying novel treatment options like stem cell therapy, and examining the mechanism of action of these novel therapies. These projects have laid a foundation of knowledge on how to apply urodynamic studies for modeling and the impact of treatments from the cellular level to the major phenomenal functioning level.
Her further interests is in investigating patient targeted therapy development and in discovering pathways to modulate neuronal signals to overcome the underlying dysfunctional pathology.